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However, since long-acting GLP-1RAs like liraglutide and semaglutide have little effect on gastric emptying, this seems unlikely to be the mechanism by which all GLP-1RAs reduce energy intake and mediate weight loss (140)

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A small miscalculation here can cascade into skewed results, wasted materials, and compromised research integrity

When E2 (i.c.v.) was supplemented, glucose intolerance was improved in OVX- Orexin +/+ but not OVX- Orexin -/- mice in the obese state

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