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In MM, SPRED1 loss rarely co-occurs with BRAF mutations, NRAS mutations, or NF1 inactivation mutations ( NF1 , around 30% of MM cases with SPRED1 inactivation simultaneously exhibit KIT alterations, suggesting that SPRED1 inactivation may be in collaboration with other oncogenic events to stimulate tumor development (100)

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CagriSema: This is a combination treatment which involves cagrilinitide and semaglutide that mimic proteins such as amylin and GLP-1

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