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In vivo bioavailability and in vitro toxicological evaluation of the new butyric acid releaser N-(1-carbamoyl-2-phenyl-ethyl) butyramide

10.1038/nchembio.2239 44

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The active-site cavity, which is located between the two domains, comprises a glutathione binding site (G-site), formed mainly by the N-terminal domain, and a hydrophobic substrate-binding site (H-site), which is formed by the C-terminal domain