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Cardiovascular (Heart and Blood Vessel) Complications In rare but serious cases, B12 replacement can lead to heart and blood vessel problems: Shortness of breath Peripheral edema (swelling in legs and arms) Rapid weight gain Pulmonary edema (fluid in lungs) Congestive heart failure (heart cannot pump effectively) Blood clots in vessels These complications arise from increased blood volume, thicker blood, and sudden changes in how hard the heart needs to work

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But, if they dont or get worse, its important to talk to a doctor

Spirulina platensis peptide-loaded nanoliposomes alleviate hepatic lipid accumulation in Male wistar rats by influencing redox homeostasis and lipid metabolism via the AMPK signaling pathway