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The abnormal architecture of the tumor vasculature results in hypoxia, immune exclusion, and poor drug delivery, thus promoting therapeutic resistance (128)

Both approaches involve the attempt to remove malignant cells and spare normal tissues, though this remains difficult due to the heterogeneity of tumour s, intrinsic drug resistance and the ability of normal tissues to be affected adversely by anticancer treatments

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[DOI] [PMC free article] [PubMed] [Google Scholar] 144.Ishihara S., Hata K., Hirose K., Okui T., Toyosawa S., Uzawa N., Nishimura R., Yoneda T

10.2337/db17-1385 [DOI] [PMC free article] [PubMed] [Google Scholar] Alexander, S

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