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Treatment with the monoclonal antibodies natalizumab (Tysabri) for therapy of MS and vedolizumab (Entyvio) for IBD, which inhibit alpha4beta1 and alpha4beta7, respectively, has been found to be efficient in the clinic for therapy of chronic relapsing inflammation of demyelinating MS disorders and treatment of resistant Crohns disease

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Lamport DJ, Breese E, Giao MS, Chandra S, Orchard F

doi: 10.1186/1743-7075-2-34

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According to the study, the most common adverse effects reported by patients include nausea, vomiting, diarrhea, constipation, and abdominal pain