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[PubMed: 36321995] (41 year old woman developed fatigue 2 months after starting ashwagandha and progesterone and stopped therapy but continued to have symptoms and then jaundice one month later [bilirubin 10.4 rising to 24.6 mg/dL, ALT 3400 U/L, Alk P 102 U/L] and 10 days later with progressive hepatic failure [encephalopathy and INR 6.2], undergoing successful emergency liver transplantation)

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Copper peptides GHK-CU similarly target collagen synthesis through different mechanisms and are sometimes used alongside GLP-1 therapy for skin quality

It can activate AMPK which helps cells take up glucose and use energy more efficiently

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