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M., Tansey, M
GLP-1 and alcohol cravings Clinical research demonstrates impressive results for GLP-1 medications in reducing alcohol consumption
Schiffman SS
Semaglutide Alternatives Between a high price tag, tight supply (Mounjaro and Zepbound are both showing limited availability through the second quarter) and general uneasiness about the unknown and possible long-term effects of weight loss medications, some products have begun to hit the market offering an affordable alternative
NICE guideline CG189 (Obesity: identification, assessment and management) recommends that prescription-strength orlistat 120 mg be considered for adults with a BMI of 30 kg/m or above, or 28 kg/m or above in the presence of weight-related risk factors such as type 2 diabetes or hypertension, within a structured weight management programme
What has changed is not the feasibility of developing drugs without complete biological knowledge, but the expectation that developers be transparent about what is and is not known, and that uncertainty be actively managed rather than minimized (ICH E9 guidance
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