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Diacylglycerol and ceramide accumulation Consistent with the above studies, elevated plasma fatty acid concentrations can result in increased intracellular diacylglycerol (DAG) levels, leading to the activation of protein kinase C isoform (PKC-) and PKC- isoforms in skeletal muscles and liver respectively

In addition, serine metabolism to cystathionine, cysteine, and GSH as traced with 13 C 3 -serine showed no detectable GSH biosynthesis from the TSS pathway (Supplementary Fig

Receptor heteromerization in adenosine A2A receptor signaling: relevance for striatal function and Parkinsons disease

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GLP-1RAs contribute to metabolic adjustments in MASLD by controlling fat deposition, inflammation, and potentially fibrosis