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Quantitative aspects of chemical carcinogenesis and tumor promotion in liver

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Together, the increase in glycolysis and decrease in TCA cycle utilization of pyruvate is reminiscent of the Warburg effect that occurs in some cancers, in which the two major metabolic pathways become uncoupled to maintain ATP production while increasing metabolic plasticity [3136]

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Some experienced huge reductions in liver fat, whereas others displayed more modest changes