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"They can lead to substantial weight loss when used in conjunction with healthy lifestyle changes in people who are overweight or have obesity with or without type 2 diabetes," says Dr

Patients often report feeling lighter, clearer, and refreshed after flushing away oxidative stress and restoring cellular balance

Dehydration can accelerate kidney function decline and is a known risk with GLP-1 agonists due to gastrointestinal effects like nausea and vomiting

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Notably, the upregulated metabolites were related primarily to glutathione metabolism, including key precursors for glutathione synthesis ( -glutamylcysteine and acetylcysteine), metabolites involved in glutathione catabolism and its byproducts (cysteinylglycine and Cys-Gly), and both oxidized and reduced forms of glutathione (GSSG and GSH) and glutathione disulfide