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Since these chemical messengers released by your mast cells produce both a local and systemic effect symptoms of histamine intolerance can be confusing and difficult to diagnosis

NewAllergy & Cognitive Neuroscience 29 June 2026 Dihexa for Hay Fever & Antihistamine Brain Fog: Allergic Rhinitis, Histamine, the Anticholinergic-Dementia Link & the 2026 UK Review Around 16 million people in the UK have hay fever and hay fever brain fog has two sources: the allergy and the medicine

That does not make it an approved treatment, but it does make it easier to study as a defined research compound

Mitochondrial DNA lacks many protective histones and is particularly vulnerable to oxidative damage

DOI: 10.1016/j.brainres.2015.07.005 36