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A randomized trial assessing the effect of tirzepatide (Mounjaro/Zepbound) found that withdrawing tirzepatide led to substantial regain of lost weight in less than two years

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(Previously, Ozempic was being used for weight loss but had only been approved for diabetes.) In the years following approval, a growing number of household names from Oprah to Elon Musk spoke publicly about their positive experiences using GLP-1s for weight loss

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