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When both peptides upregulate VEGF through different pathways, the combined effect may exceed simple addition

[8] Although not an absolute contraindication, patients with coronary artery disease or unstable angina should only use B-Complex injections containing niacinamide under physician supervision, since high-dose niacin supplements have been linked to arrhythmias in such patients

Although extremely rare, hydroxocobalamin injections can also cause serious side effects such as a major allergic reaction or irregular heartbeats (palpitations)

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Vitamin B12, for instance, is crucial as it promotes the development of the nervous system and the brain in unborn babies