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Many people experience weight regain when GLP-1s are discontinued without an effective lifestyle program, which can undermine the long-term value of the investment

J Comp Neurol 395:535547 Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, Barsh GS (1997) Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

the latter enzyme is currently being considered in other cancer types as well 3,222