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This is intracellular water in muscle tissue, not the kind of water retention associated with inflammation or cardiovascular issues

Oral semaglutide should be considered as second-line therapy after metformin, particularly when weight is an issue and possibly in those at higher cardiovascular risk

[1] [2] During the first month of semaglutide treatment, patients typically experience modest but noticeable weight loss as the medication is initiated at lower doses

Food stays in the stomach longer, which extends fullness and reduces appetite

(4) The fatty acid chain of semaglutide then likely anchors the peptide to the membrane, with SNAC molecules in the membrane creating a quicksand-like effect, enabling the peptide to slowly sink into the membrane