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After that, in order to validate the model, we simulate the system of equations with the estimated parameter values and calculate goodness of fit of the [GSH] and [GSSG] simulation results to the validation set
Diclofenac and omeprazole based validation of the Nrf2 model Since we are interested in the role of Nrf2 signaling in DILI, we set out to validate the constructed model as based on the general ROS-inducer DEM with two DILI inducing compounds
This is for educational purposes
Epilepsia 2009;50:13011309
Abstract Diminished bioavailability of nitric oxide (NO), the gaseous signaling molecule involved in the regulation of numerous vital biological functions, contributes to the development and progression of multiple age- and lifestyle-related diseases
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