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Nrf1 is critical for redox balance and survival of liver cells during development

Common areas of evaluation may include hormone levels, thyroid function, blood sugar regulation, cholesterol levels, vitamin and nutrient levels, inflammatory markers, and other indicators of metabolic health

Int J Clin Pharmacol Ther Toxicol 1988;26:217-20

It is administered as a once-weekly subcutaneous injection in clinical trials, a delivery method consistent with other agents in the incretin-based therapy class, such as semaglutide and tirzepatide

Otto EPP, Ladenstein R, Wendel A

To ensure patients were not given a GLP-1 agonist and discontinued use before therapeutic benefit, patients were filtered by those with documented GLP-1 agonist use at least twice and at least three months apart after diagnosis of MASLD/MASH