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Although various therapeutic modality including systemic and topical pharmacological and procedural treatments are commonly available for melasma management, however, many of these treatments showed limited clinical response and accompany numerous unwanted adverse drug reactions

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doi: 10.1097/AOG.0000000000002633 73

doi: 10.1016/j.bbi.2023.05.006

Oral delivery will not only improve patient compliance and broaden access, but it can also cut the manufacturing bill and reduce environmental impact through the elimination of injectable device disposal

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