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[PubMed: 8786016] (Among 328 patients with diabetic peripheral neuropathy treated with ALA [100, 600, or 1200 mg] or placebo intravenously 4 to 5 days per week for 3 weeks, total neuropathy symptom scores improved by 43%, 63% and 58% with ALA vs 38% with placebo, while adverse events were similar with the lower doses as with placebo [14% and 18% vs 21%] but higher with the highest dose [33%]

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Severe Hypokalemia: A Critical Drop in Potassium Levels One of the most serious complications of B12 replacement therapy in severe megaloblastic anemia (a type of anemia where blood cells are abnormally large) is the development of severe hypokalemia (dangerously low potassium levels in the blood)