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Furthermore, its short half-life of less than 3 h (Min et al., 2025) necessitates twice-daily injections to maintain efficacy, which can be a limiting factor for long-term patient adherence

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In simpler terms, each heartbeat pushes more blood with more force

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Bottom line: Your body needs a constant supply of the reduced form to keep the "recycling" process moving and protect your cells from daily environmental stress