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This has led to extensive research on its oral bioavailability and efficacy, particularly for gut-related issues but also for systemic healing

For example, while curcumin has strong NFB and Nrf2 modulation capabilities, its limited bioavailability necessitates formulation enhancements for clinical application (McGrattan et al

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The therapeutic effects and antioxidant properties of epigallocatechin-3 gallate: A new review

Genetic variation in the GLP1R gene (rs6923761), GIPR receptor pathway (rs1800437), and appetite-regulation genes like FTO (rs9939609) and MC4R (rs17782313) influence individual response rates and side effect tolerance

PMID 14482007