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It has been suggested that it may be possible to use less toxic therapies at a lower threshold of disease severity

doi: 10.1006/abio.1993.1529 53 MhamdiA.HagerJ.ChaouchS.QuevalG.HanY.TaconnatL.et al

Reilly, Evidence for Functionally Significant Polymorphism of Human Glutamate Cysteine Ligase Catalytic Subunit: Association with Glutathione Levels and Drug Resistance in the National Cancer Institute Tumor Cell Line Panel