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IGF-1 LR3 is used in oncological research to screen competitive inhibitors, study chemotherapy resistance and characterize interactions between IGF pathway and EGFR/HER2 pathways

1 Guidelines, manufacturers, and FDA warnings have erred on the side of caution and recommend careful use of GLP-1 RAs in patients with a history or high risk of pancreatitis

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The pathogenesis of MASLD is complex, involving lipotoxicity, OS, insulin resistance (IR), and changes in the gut microbiota (GM) (Figure 1), which schematically illustrates the multifactorial etiology and key risk factors including obesity, insulin resistance, and hyperlipidemia