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Sharma A, Anand SK, Singh N, Dwivedi UN, Kakkar P (2023) AMP-activated protein kinase: an energy sensor and survival mechanism in the reinstatement of metabolic homeostasis

Two GLP-1 medications can produce different results for the same person because real-world results depend on whether you can take the medication consistently for months

Stachenfeld, N.S

GLP-1 support works best alongside regular movement (specifically, resistance or strength training), adequate protein intake, fiber-rich foods, and sleep

So to answer your question directly, there are some people who probably don't have that thrifty gene, but just the fact of how their lifestyle is they're not physically active, they're eating a lot of highly processed food and so forth they're gaining weight, but that can change quickly depending upon change in their behavior and in their environment

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