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JAMA Netw Open 2022;5(9):e2231982

[4] Eli Lilly

Regulation of appropriate pathways downstream of the ER could also be an effective therapeutic strategy regardless of sex

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DAGs activate protein kinase C (PKC) isoforms that serine-phosphorylate and inhibit the insulin receptor substrate 1 (IRS-1), while ceramides activate Protein Phosphatase 2A (PP2A), which dephosphorylates and deactivates Akt, thereby locally exacerbating IR and promoting further atrophy (56, 62)

Check with your clinician before using large volumes of fluids if you have heart or kidney disease