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Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome

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Teixeira MI, Lopes CM, Amaral MH, Costa PC

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FOXO3a itself induces a set of atrophy-related genes, specifically the muscle-specific ubiquitin ligases, MAFbx and MuRF-1, which promote the breakdown of the myofibrillar apparatus [17]

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