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Kawasaki and Kawai, 2014

What if the peptide doesnt dissolve

From the argonauts mythological sailors to the argonautes RNA-silencing navigators: their emerging roles in human-cell pathologies

doi: 10.1007/s13277-015-4395-x 65 SenaPManciniSBenincasaMMarianiFPalumboCRoncucciL

On conjugation of glycine & ester produced compounds 22A and 22B with identical inhibition potency, however introducing proline in both conformations, whether R or S displayed lower potency of compounds with an IC 50 of 19.1 & 34.6 nM, whereas their esters led to a reduction in DPP-4 inhibition