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For people with severe renal impairment (eGFR below 30 mL/min/1.73 m) or those on dialysis, the evidence base for most weight loss medications is limited, and many are either contraindicated or lack sufficient safety data

Weight loss tends to be faster in the early months, likely due to the additional GIP receptor activity

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If youre comparing Mounjaro injection to the Wegovy pill, Mounjaro produces greater average weight loss (22.5% vs 13.6%), but it requires weekly injections

But much of what gets reported as lean mass loss has not been proven to be skeletal muscle loss

That is why GLP-1 arms are essential for modeling metabolic and obesity endpoints in Canadian research