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6 Diagnosis typically involves polysomnography, which measures AHI to determine OSA severity (mild: 5-15 events/hour

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( E ) Relative quantification of M0 propionylcarnitine (C3) with D9 carnitine as an internal standard

These rates compare favorably with the Phase 2 discontinuation rates (10-17%), likely reflecting the improved dose-escalation schedules used in Phase 3

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