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Additionally, mazdutide has been tested in head-to-head trials against semaglutide, providing insight into how it performs against the most widely used GLP-1 agonist

Key advantages: Oral administration (no injection burden) Scalable manufacturing Potential for combination therapies Broader patient adherence However, these molecules also reintroduce important questions: Will small-molecule receptor activation alter tissue selectivity

And although the drugs reduce hunger, patients on GLP-1s should still eat three meals a day and stay hydrated

The American Society of Anesthesiologists suggests withholding GLP-1 medications before elective surgery to reduce the risk of complications, and this is something your doctor can help with, should you have an upcoming operation

Some studies show that up to 40% of the weight loss observed in patients on semaglutide is attributable to loss of lean muscle mass, which is viewed as a major shortcoming

Endocrinology 149 (8), 40594068