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In our clinical practice, a baseline brain MRI is offered to patients with large CMN overlying the lower spine which may prompt referral to neurology or ongoing monitoring, although some parents choose to forego imaging given the limited available interventions

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On induction with interferon- (IFN-), the constitutive 1, 2 and 5 subunits of 20S proteasome are replaced by catalytically active inducible 1i (PSMB9), 2i (PSMB10) and 5i (PSMB8) subunits referred as the immunoproteasome 24,25

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