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Open questions in the GHK-Cu field include the specific cellular targets responsible for the broad transcriptomic effects, the relationship between the copper-delivery role and the direct peptide-only effects (if any), the comparative biology of GHK-Cu and related copper-peptides in defined cellular contexts, and the translation of cell-culture and animal-model findings to clinical-research endpoints under controlled study conditions

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Methylfolate supports methylationbut DNA synthesis requires folinic acid

doi:10.1054/ghir.1999.9998 Greenwood-Van Meerveld B, Tyler K, Mohammadi E, Pietra C

However, not all vitamin C creates this problem

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