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Cell 177 , 16821699 (2019)

Additionally, SRY-box transcription factor 9 (Sox9) and Krppel-like factor 4 (Klf4) transcription factors, are Paneth and goblet cell-specific differentiation factors [22, 23]

[13] These findings are further reinforced by pharmacovigilance data from the FDA Adverse Event Reporting System (FAERS) database (n=48,214 reports), where GLP-1RA-related gastrointestinal adverse events, including nausea (9651 vs 38,030) and vomiting (4383 vs 17,062), were lower with combination therapy compared to GLP-1RA monotherapy, suggesting improved tolerability when metformin is added