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Consistent with Oga deletion, pharmacological inhibition of Oga, which induces acute elevation of O-GlcNAcylation, has been shown to attenuate hippocampal activity by diminishing the intrinsic excitability of CA1 neurons and excitatory synaptic transmission at Schaffer collateral-CA1 synapses [80]

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10.1016/s1542-0124(12)70185-4 Fogagnolo P, Sacchi M, Ceresara G, Paderni R, Lapadula P, Orzalesi N, Rossetti L: The effects of topical coenzyme Q10 and vitamin E D--tocopheryl polyethylene glycol 1000 succinate after cataract surgery: a clinical and in vivo confocal study

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This typically occurs: For individuals assigned female at birth- after consuming 4 or more drinks in a 2-hour period For individuals assigned male at birth- after consuming 5 or more drinks in a 2-hour period