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Effect of neoadjuvant chemotherapy plus regional hyperthermia on long-term outcomes among patients with localized high-risk soft tissue sarcoma: the EORTC 62961-ESHO 95 randomized clinical trial

Increasing preference among healthcare providers for long-acting GLP-1 therapies has further strengthened demand

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Nevertheless, given residual heterogeneity and the inherent limitations of network meta-analyses, further randomized trials are needed to confirm these findings, define relative effects versus individual GLP-1RAs, and clarify the role of tirzepatide across broader cardiometabolic populations

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Pharmacokinetic and toxicological studies using standardized extract should be performed before they can be subjected to clinical studies