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Simultaneously, there is an enhancement of the expression of heat shock proteins (e.g., HSP70 and HSP90) and antioxidant proteins (e.g., heme oxygenase (HO-1), NAD(P)H dehydrogenase (NQO-1), glutathione reductase, glutathione peroxidase 2, and glutathione S-transferase pi (GST-pi)) [18]

NICE guidance (NG49) and NHS resources emphasise these interventions as first-line management, with no specific supplements currently recommended as standard treatment for NAFLD

But here is where things get complicated with Anthem specifically

Sparkling water seems healthy

The dual receptor activity offers a synergistic approach, potentially resulting in more significant weight loss and improved metabolic outcomes compared to therapies targeting a single receptor pathway

Across STEP-1 and other trials (STEP-3, 4, and 8), average weight loss ranged between 14.9% and 17.4% at 68 weeks