(2020) and Petitprez et al
Significantly elevated homocysteine has been observed in people suffering with cardiovascular disease, stroke, neurodegeneration (Nelson et al, 2016) and frailty in old age (Guaita et al, 2021) and elevated homocysteine is associated with a reduced blood flow to the small vessels in the brain (reduced microcirculation) (Hassan et al, 2004) which is an important connection because a reduced microcirculation may increase the risk of developing Alzheimers disease, amyotrophic lateral sclerosis (ALS) or Parkinsons disease (Erdener and Dalkara, 2019)
Because of this, most manufacturers state that unopened vials can be stored at controlled room temperature (around 20C to 25C or 68F to 77F)
Compare this to the recommended daily dietary copper intake of 900 mcg for adults per the National Institutes of Health Office of Dietary Supplements [12]
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[13] Volkova A, Shadrina M, Kolomin T, Andreeva L, Limborska S, Myasoedov N, Slominsky P
