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16 However, despite these improvements in CVD risk factors and modest weight loss, reductions in cardiovascular outcomes were not demonstrated, so the trial was discontinued at a median follow up of 9.6 years following a futility analysis

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Abstract Background: Respiratory adverse events associated with programmed cell death protein 1 and programmed death-ligand 1 (PD-1/PD-L1) inhibitors have emerged as an important safety concern in clinical oncology