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What this means for clinical research: Clinical development in 2026 is increasingly geographically modular, requiring sponsors and CROs to coordinate multi-region strategies earlier and manage data, quality, and regulatory alignment across jurisdictions

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Retatrutide's discontinuation rate in SURMOUNT-5 was 12.4%, compared to 7.1% for tirzepatide in SURMOUNT-1 and 4.5% for semaglutide in STEP 1

Therapeutic targeting of ferroptosis in ARDS includes the use of antioxidants, GPX4 activators, iron chelators, and inhibitors of lipid peroxidation

MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer