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These advances may allow us to identify earlier physiologic changes, personalize treatment, and ultimately improve long-term neurological outcomes

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Research published in Obesity found that after sustained caloric restriction, participants burned an average of 121 fewer calories per day than predicted based on body size alone. A 2025 commentary in Cell Reports Medicine confirmed that GLP-1 therapies specifically can reduce total energy expenditure through this same adaptive process, even while appetite remains suppressed. The plateau is often not a sign the medication stopped working

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