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Laser hair removal is not effective for individuals with light blond, grey or silver hair, but it can safely be performed on people of all skin types and tones, with very rare exceptions for this who have specific rare diseases

Semaglutide (Ozempic/Wegovy) Timeline Phase 3 trials began: 2015 (SUSTAIN program for diabetes) FDA approval (Ozempic for diabetes): December 2017 Commercial availability: Early 2018 Wegovy (obesity indication) Phase 3: 2018-2020 (STEP program) Wegovy FDA approval: June 2021 Wegovy commercial launch: September 2021, immediately went into shortage due to overwhelming demand Stable widespread availability: Mid-2023 (after Novo Nordisk scaled up manufacturing) Total time from Phase 3 start to stable availability: About 8 years for diabetes indication, 5 years for obesity indication (but with significant supply constraints)

Most users may begin noticing visible benefits such as improved skin radiance and vitality after 4 to 8 weeks of regular use

doi: 10.1002/14651858.CD006787.pub2

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