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Weight & glycemic control: robust randomized control trials (RCTs) show large, clinically meaningful weight loss and A1C reduction with semaglutide and tirzepatide for people with obesity and/or type 2 diabetes

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[1] [2] Treatment intensification should follow a stepwise approach , typically starting with metformin and adding further agents based on individual patient factors such as HbA1c levels, cardiovascular risk, renal function, and patient preference

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Vascular senescence in cardiovascular and metabolic diseases