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Exposure to chemicals and other pollutants can increase the demand for the bodys antioxidants, while autoimmune diseases have also been shown to deplete glutathione

On the other hand, the higher activity of Mn-SOD clearly made the difference between a salt-tolerant cultivar and a salt-sensitive cultivar of tomato under salinity stress (Mittova et al., 2003)

Vitamin D signaling system genes, which has large CpG islands in their promoter regions and is prone to be regulated by DNA methylation and therefore can be silenced by de novo methylation 32,33,34,35

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