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Among the sophisticated machines are several large pods that resemble futuristic sarcophagi, one of which spins slowly, dreamily, behind a large glass divider

These limitations underscore the need for delivery innovations such as nanoparticle encapsulation, liposomal formulations, and prodrug designs to enhance bioavailability, protect compounds from first-pass metabolism, and improve tissue-specific targeting

In terms of efficacy, DexL and DexN did not differ significantly ( p = 0.32)

Cessation of opioids leaves the brain with a deficit of dopamine, the neurotransmitter associated with pleasure and reward

doi: 10.1016/j.jconrel.2008.10.015

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