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Red areas indicate increased cFOS activity and blue areas indicate decreased cFOS activity

Genome-wide association studies and sequencing have identified more than 260 susceptibility loci for inflammatory bowel disease (IBD), enriched for genes involved in innate and adaptive immunity and immune signaling (e.g., IL23R, JAK2, TNFSF18

Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype

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