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Intestinal barrier dysfunction leads to the translocation of gut bacteria and endotoxins (Lipopolysaccharide, LPS) into the bloodstream, which specifically activate Kupffer cells (KCs) in the liver of both heatstroke patients and mouse models

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Excess homocysteine contributes to oxidative damage in pancreatic -cells, impairing insulin secretion

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Satriano A, Franchini S, Lapergola G, Pluchinotta F, Anastasia L, Baryshnikova E, et al