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Individuals with certain variants may require higher supplementation doses to achieve equivalent circulating 25(OH)D levels

ARA 290 has been evaluated extensively in a wide spectrum of preclinical models, including diet-induced insulin resistance (10), diabetic retinopathy (11), diabetic autonomic neuropathy (12), myocardial infarction (13), chronic heart failure (14), burns (15), traumatic brain injury (16,17) and shock-induced multi-organ failure (18), among others

Dose-Reduced DOACs in Special Populations The effects of dose-reduced DOACs in specific patient groups deserve attention

10.1002/hep.26625 Hepatology 63 SaitoC.LemastersJ

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Healthcare providers should consider this limited evidence base when making treatment decisions and should discuss these limitations with patients