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Concurrently, SPAE upregulated AMPK expression, which was suppressed by DEX administration

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Research has investigated its mechanism via central melanocortin pathways, with studies examining behavioural and physiological responses mediated through MC4R signalling

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Subsequently, the IL-10 receptor/STAT3 signaling pathway in microglia is autocrinally activated, thereby promoting the expression and release of -endorphin, the latter acts on -opioid receptors on neurons to produce analgesic and neuroprotective effects (103105)