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Individual clinical judgment determines whether benefits outweigh risks in these populations

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semaglutide drove a significant reduction in femoral BMD that was associated with lower cortical thickness, but no changes in trabecular bone by extreme CT

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Just make sure to remain hydrated and avoid overdoing it

As you lose weight, your metabolic rate drops both from having less body mass and from adaptive thermogenesis, your body actively reducing energy expenditure to defend against further loss